Organ |
liver |
Age classes |
adolescent |
Gender |
F+M |
Condition |
8 weeks |
phase I metabolism > CYP3A > omeprazole sulphoxidation > microsomes |
11.9 pmol/min/mg protein (sd=3.3)
|
Turpeinen et al., 2007 - Turpeinen, M., Ghiciuc, C., Opritoui, M., Tursas, L., Pelkonen, O. and Pasanen, M. (2007) Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: a comparative study in vitro. Xenobiotica 37, 1367-77.
|
phase I metabolism > CYP3A > midazolam α-hydroxylation > microsomes |
1509 pmol/min/mg protein (sd=446)
|
Turpeinen et al., 2007 - Turpeinen, M., Ghiciuc, C., Opritoui, M., Tursas, L., Pelkonen, O. and Pasanen, M. (2007) Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: a comparative study in vitro. Xenobiotica 37, 1367-77.
|
phase I metabolism > CYP2E1 > chlorzoxazone 6-hydroxylation > microsomes |
833 pmol/min/mg protein (sd=144)
|
Turpeinen et al., 2007 - Turpeinen, M., Ghiciuc, C., Opritoui, M., Tursas, L., Pelkonen, O. and Pasanen, M. (2007) Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: a comparative study in vitro. Xenobiotica 37, 1367-77.
|
phase I metabolism > CYP2D6 > dextromethorphan O-demethylation > microsomes |
227 pmol/min/mg protein (sd=35)
|
Turpeinen et al., 2007 - Turpeinen, M., Ghiciuc, C., Opritoui, M., Tursas, L., Pelkonen, O. and Pasanen, M. (2007) Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: a comparative study in vitro. Xenobiotica 37, 1367-77.
|
phase I metabolism > CYP2C9 > tolbutamide hydroxylation > microsomes |
0.82 pmol/min/mg protein (sd=2)
|
Turpeinen et al., 2007 - Turpeinen, M., Ghiciuc, C., Opritoui, M., Tursas, L., Pelkonen, O. and Pasanen, M. (2007) Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: a comparative study in vitro. Xenobiotica 37, 1367-77.
|
phase I metabolism > CYP2C19 > omeprazole 5-hydroxylation > microsomes |
20 pmol/min/mg protein (sd=5.7)
|
Turpeinen et al., 2007 - Turpeinen, M., Ghiciuc, C., Opritoui, M., Tursas, L., Pelkonen, O. and Pasanen, M. (2007) Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: a comparative study in vitro. Xenobiotica 37, 1367-77.
|
phase I metabolism > CYP2B > pentoxyresorufin O-depentylation > microsomes |
2.9 pmol/min/mg protein (sd=0.44)
|
Turpeinen et al., 2007 - Turpeinen, M., Ghiciuc, C., Opritoui, M., Tursas, L., Pelkonen, O. and Pasanen, M. (2007) Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: a comparative study in vitro. Xenobiotica 37, 1367-77.
|
phase I metabolism > CYP2B > bupropion hydroxylation > microsomes |
62 pmol/min/mg protein (sd=22)
|
Turpeinen et al., 2007 - Turpeinen, M., Ghiciuc, C., Opritoui, M., Tursas, L., Pelkonen, O. and Pasanen, M. (2007) Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: a comparative study in vitro. Xenobiotica 37, 1367-77.
|
phase I metabolism > CYP2A6 > coumarin 7-hydroxylation > microsomes |
52 pmol/min/mg protein (sd=15)
|
Turpeinen et al., 2007 - Turpeinen, M., Ghiciuc, C., Opritoui, M., Tursas, L., Pelkonen, O. and Pasanen, M. (2007) Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: a comparative study in vitro. Xenobiotica 37, 1367-77.
|
phase I metabolism > CYP1A1 > ethoxyresorufin O-deethylation > microsomes |
172 pmol/min/mg protein (sd=56)
|
Turpeinen et al., 2007 - Turpeinen, M., Ghiciuc, C., Opritoui, M., Tursas, L., Pelkonen, O. and Pasanen, M. (2007) Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: a comparative study in vitro. Xenobiotica 37, 1367-77.
|
phase I metabolism > CYP1A > 7-ethoxycoumarin O-deethylation > microsomes |
4.4 pmol/min/mg protein (sd=1.2)
|
Turpeinen et al., 2007 - Turpeinen, M., Ghiciuc, C., Opritoui, M., Tursas, L., Pelkonen, O. and Pasanen, M. (2007) Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: a comparative study in vitro. Xenobiotica 37, 1367-77.
|