Organ |
liver |
Age classes |
adolescent |
Gender |
F+M |
Condition |
8 weeks |
phase I metabolism > CYP3A > midazolam α-hydroxylation > microsomes |
135 pmol/min/mg protein (sd=112)
|
Turpeinen et al., 2007 - Turpeinen, M., Ghiciuc, C., Opritoui, M., Tursas, L., Pelkonen, O. and Pasanen, M. (2007) Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: a comparative study in vitro. Xenobiotica 37, 1367-77.
|
phase I metabolism > CYP2E1 > ethoxycoumarin O-deethylation > microsomes |
34 pmol/min/mg protein (sd=9.7)
|
Turpeinen et al., 2007 - Turpeinen, M., Ghiciuc, C., Opritoui, M., Tursas, L., Pelkonen, O. and Pasanen, M. (2007) Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: a comparative study in vitro. Xenobiotica 37, 1367-77.
|
phase I metabolism > CYP2E1 > chlorzoxazone 6-hydroxylation > microsomes |
263 pmol/min/mg protein (sd=74)
|
Turpeinen et al., 2007 - Turpeinen, M., Ghiciuc, C., Opritoui, M., Tursas, L., Pelkonen, O. and Pasanen, M. (2007) Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: a comparative study in vitro. Xenobiotica 37, 1367-77.
|
phase I metabolism > CYP2D6 > dextromethorphan O-demethylation > microsomes |
155 pmol/min/mg protein (sd=101)
|
Turpeinen et al., 2007 - Turpeinen, M., Ghiciuc, C., Opritoui, M., Tursas, L., Pelkonen, O. and Pasanen, M. (2007) Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: a comparative study in vitro. Xenobiotica 37, 1367-77.
|
phase I metabolism > CYP2C9 > tolbutamide hydroxylation > microsomes |
54 pmol/min/mg protein (sd=21)
|
Turpeinen et al., 2007 - Turpeinen, M., Ghiciuc, C., Opritoui, M., Tursas, L., Pelkonen, O. and Pasanen, M. (2007) Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: a comparative study in vitro. Xenobiotica 37, 1367-77.
|
phase I metabolism > CYP2C19 > omeprazole 5-hydroxylation > microsomes |
13 pmol/min/mg protein (sd=2.7)
|
Turpeinen et al., 2007 - Turpeinen, M., Ghiciuc, C., Opritoui, M., Tursas, L., Pelkonen, O. and Pasanen, M. (2007) Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: a comparative study in vitro. Xenobiotica 37, 1367-77.
|
phase I metabolism > CYP2B > pentoxyresorufin O-depentylation > microsomes |
1.5 pmol/min/mg protein (sd=0.53)
|
Turpeinen et al., 2007 - Turpeinen, M., Ghiciuc, C., Opritoui, M., Tursas, L., Pelkonen, O. and Pasanen, M. (2007) Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: a comparative study in vitro. Xenobiotica 37, 1367-77.
|
phase I metabolism > CYP1A1 > ethoxyresorufin O-deethylation > microsomes |
47 pmol/min/mg protein (sd=15)
|
Turpeinen et al., 2007 - Turpeinen, M., Ghiciuc, C., Opritoui, M., Tursas, L., Pelkonen, O. and Pasanen, M. (2007) Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: a comparative study in vitro. Xenobiotica 37, 1367-77.
|