Organ |
liver |
Age classes |
adolescent |
Gender |
M |
Condition |
9-11 weeks |
phase I metabolism > CYP3A4 > dextromethorphan N-demethylation > microsomes |
1609 pmol/min/mg protein (sd=595)
|
Zhang et al., 1999 - Zhang, W., Parentau, H., Greenly, R.L., Metz, C.A., Aggarwal, S., Wainer, I.W. and Tracy, T.S. (1999) Effect of protein-calorie malnutrition on cytochromes P450 and glutathione S-transferase. Eur J Drug Metab Pharmacokinet 24 , 141-7.
|
phase I metabolism > CYP2E1 > chlorzoxazone 6-hydroxylation > microsomes |
2003 pmol/min/mg protein (sd=796)
|
Zhang et al., 1999 - Zhang, W., Parentau, H., Greenly, R.L., Metz, C.A., Aggarwal, S., Wainer, I.W. and Tracy, T.S. (1999) Effect of protein-calorie malnutrition on cytochromes P450 and glutathione S-transferase. Eur J Drug Metab Pharmacokinet 24 , 141-7.
|
phase I metabolism > CYP2D6 > dextromethorphan O-demethylation > microsomes |
353 pmol/min/mg protein (sd=217)
|
Zhang et al., 1999 - Zhang, W., Parentau, H., Greenly, R.L., Metz, C.A., Aggarwal, S., Wainer, I.W. and Tracy, T.S. (1999) Effect of protein-calorie malnutrition on cytochromes P450 and glutathione S-transferase. Eur J Drug Metab Pharmacokinet 24 , 141-7.
|
phase II metabolism > GST > chlorodinitrobenzene glutathion conjugation > cytosol |
0.5 pmol/min/mg protein (sd=0.1)
|
Zhang et al., 1999 - Zhang, W., Parentau, H., Greenly, R.L., Metz, C.A., Aggarwal, S., Wainer, I.W. and Tracy, T.S. (1999) Effect of protein-calorie malnutrition on cytochromes P450 and glutathione S-transferase. Eur J Drug Metab Pharmacokinet 24 , 141-7.
|