Organ |
liver |
Age classes |
adolescent |
Gender |
M |
phase I metabolism > NADPH-cytochrome P450 reductase > microsomes |
10.34 nmol/min/mg protein (sd=0.02) (k-90%=1.1)
|
Zhang et al., 1999 - Zhang, W., Parentau, H., Greenly, R.L., Metz, C.A., Aggarwal, S., Wainer, I.W. and Tracy, T.S. (1999) Effect of protein-calorie malnutrition on cytochromes P450 and glutathione S-transferase. Eur J Drug Metab Pharmacokinet 24 , 141-7.
Gamez et al., 2004 - Gamez, R., Rodeiro, I., Gonzalez, J. and Garcia, H. (2004) Effects of D-003 on hepatic drug-metabolizing enzyme activities in rats. J Med Food 7, 482-6.
|
phase I metabolism > CYP1A1 > ethoxyresorufin O-deethylation > microsomes |
7.68 pmol/min/mg protein (sd=4.9)
|
Gamez et al., 2004 - Gamez, R., Rodeiro, I., Gonzalez, J. and Garcia, H. (2004) Effects of D-003 on hepatic drug-metabolizing enzyme activities in rats. J Med Food 7, 482-6.
|
phase II metabolism > GST > chlorodinitrobenzene glutathion conjugation > cytosol |
670 pmol/min/mg protein (sd=10)
|
Gamez et al., 2004 - Gamez, R., Rodeiro, I., Gonzalez, J. and Garcia, H. (2004) Effects of D-003 on hepatic drug-metabolizing enzyme activities in rats. J Med Food 7, 482-6.
|
weight > per 100 g body weight |
2.72 g (sd=0.17)
|
Saillenfait et al., 2016 - Saillenfait, A. M., Marquet, F., Sabaté, J. P., Ndiaye, D., & Lambert-Xolin, A. M. (2016). 4-Week repeated dose oral toxicity study of N-ethyl-2-pyrrolidone in Sprague Dawley rats. Regulatory Toxicology and Pharmacology, 81, 275-283.
|
phase I metabolism > CYP3A > testosterone 6β-hydroxylation > microsomes |
872.1 pmol/min/mg protein (sd=222.1)
|
Li et al., 2018 - Li, C. C., Yu, H. F., Chang, C. H., Liu, Y. T., & Yao, H. T. (2018). Effects of lemongrass oil and citral on hepatic drug-metabolizing enzymes, oxidative stress, and acetaminophen toxicity in rats. journal of food and drug analysis, 26(1), 432-438.
|
phase I metabolism > CYP1A2 > methoxyresorufin O-demethylation > microsomes |
21.3 pmol/min/mg protein (sd=2.1)
|
Li et al., 2018 - Li, C. C., Yu, H. F., Chang, C. H., Liu, Y. T., & Yao, H. T. (2018). Effects of lemongrass oil and citral on hepatic drug-metabolizing enzymes, oxidative stress, and acetaminophen toxicity in rats. journal of food and drug analysis, 26(1), 432-438.
|
phase I metabolism > CYP2B > pentoxyresorufin O-depentylation > microsomes |
20.0 pmol/min/mg protein (sd=2.7)
|
Li et al., 2018 - Li, C. C., Yu, H. F., Chang, C. H., Liu, Y. T., & Yao, H. T. (2018). Effects of lemongrass oil and citral on hepatic drug-metabolizing enzymes, oxidative stress, and acetaminophen toxicity in rats. journal of food and drug analysis, 26(1), 432-438.
|
phase I metabolism > CYP2A > testosterone 7α-hydroxylation > microsomes |
448.7 pmol/min/mg protein (sd=11.5)
|
Huang et al., 2015 - Huang, Y., Hu, N., Gao, X., Yan, Z., Li, S., Jing, W., & Yan, R. (2015). Alterations of testosterone metabolism in microsomes from rats with experimental colitis induced by dextran sulfate sodium. Chemico-biological interactions, 232, 38-48.
|
phase I metabolism > CYP2C11 > testosterone 16α-hydroxylation > microsomes |
804.5 pmol/min/mg protein (sd=44.8)
|
Huang et al., 2015 - Huang, Y., Hu, N., Gao, X., Yan, Z., Li, S., Jing, W., & Yan, R. (2015). Alterations of testosterone metabolism in microsomes from rats with experimental colitis induced by dextran sulfate sodium. Chemico-biological interactions, 232, 38-48.
|
phase I metabolism > CYP1A1 > testosterone 6α-hydroxylation > microsomes |
587.8 pmol/min/mg protein (sd=30.7)
|
Huang et al., 2015 - Huang, Y., Hu, N., Gao, X., Yan, Z., Li, S., Jing, W., & Yan, R. (2015). Alterations of testosterone metabolism in microsomes from rats with experimental colitis induced by dextran sulfate sodium. Chemico-biological interactions, 232, 38-48.
|
phase I metabolism > CYP3A2 > testosterone 2β-hydroxylation > microsomes |
273.7 pmol/min/mg protein (sd=19.3)
|
Huang et al., 2015 - Huang, Y., Hu, N., Gao, X., Yan, Z., Li, S., Jing, W., & Yan, R. (2015). Alterations of testosterone metabolism in microsomes from rats with experimental colitis induced by dextran sulfate sodium. Chemico-biological interactions, 232, 38-48.
|
phase I metabolism > CYP3A2 > testosterone 6β-hydroxylation > microsomes |
199.7 pmol/min/mg protein (sd=8.1)
|
Huang et al., 2015 - Huang, Y., Hu, N., Gao, X., Yan, Z., Li, S., Jing, W., & Yan, R. (2015). Alterations of testosterone metabolism in microsomes from rats with experimental colitis induced by dextran sulfate sodium. Chemico-biological interactions, 232, 38-48.
|
phase I metabolism > CYP1A2 |
40.9 ng/min/mg protein (sd=4.8)
|
Wang et al., 2018 - Wang, J., Zhai, T., & Chen, Y. (2018). Effects of honokiol on CYP450 activity and transporter mRNA expression in type 2 diabetic rats. International journal of molecular sciences, 19(3), 815.
|
phase I metabolism > CYP2B |
6.96 ng/min/mg protein (sd=0.54)
|
Wang et al., 2018 - Wang, J., Zhai, T., & Chen, Y. (2018). Effects of honokiol on CYP450 activity and transporter mRNA expression in type 2 diabetic rats. International journal of molecular sciences, 19(3), 815.
|
phase I metabolism > CYP2E1 |
132.7 ng/min/mg protein (sd=33.1)
|
Wang et al., 2018 - Wang, J., Zhai, T., & Chen, Y. (2018). Effects of honokiol on CYP450 activity and transporter mRNA expression in type 2 diabetic rats. International journal of molecular sciences, 19(3), 815.
|
phase I metabolism > CYP3A |
3789.6 ng/min/mg protein (sd=733.5)
|
Wang et al., 2018 - Wang, J., Zhai, T., & Chen, Y. (2018). Effects of honokiol on CYP450 activity and transporter mRNA expression in type 2 diabetic rats. International journal of molecular sciences, 19(3), 815.
|
phase I metabolism > CYP2C |
59.9 ng/min/mg protein (sd=11.5)
|
Wang et al., 2018 - Wang, J., Zhai, T., & Chen, Y. (2018). Effects of honokiol on CYP450 activity and transporter mRNA expression in type 2 diabetic rats. International journal of molecular sciences, 19(3), 815.
|
phase I metabolism > CYP4A |
458.0 ng/min/mg protein (sd=50.3)
|
Wang et al., 2018 - Wang, J., Zhai, T., & Chen, Y. (2018). Effects of honokiol on CYP450 activity and transporter mRNA expression in type 2 diabetic rats. International journal of molecular sciences, 19(3), 815.
|