Organ |
liver |
Age classes |
adolescent |
Gender |
M |
Condition |
7 weeks |
phase I metabolism > NADPH-cytochrome P450 reductase > microsomes |
145.3 nmol cyt. c/min/mg protein (sd=6.3)
|
Chan et al., 2006 - Chan, P. K., Lu, S. Y., Liao, J. W., Wei, C. F., Tsai, Y. and Ueng, T. H. (2006) Induction and inhibition of cytochrome P450-dependent monooxygenases of rats by fungicide bitertanol. Food Chem Toxicol. 44(12), 2047-57.
|
phase I metabolism > CYP3A4 > erythromycin N-demethylation > microsomes |
0.332 pmol/min/mg protein (sd=0.034)
|
Chan et al., 2006 - Chan, P. K., Lu, S. Y., Liao, J. W., Wei, C. F., Tsai, Y. and Ueng, T. H. (2006) Induction and inhibition of cytochrome P450-dependent monooxygenases of rats by fungicide bitertanol. Food Chem Toxicol. 44(12), 2047-57.
|
phase I metabolism > CYP2C > testosterone 16α-hydroxylation > microsomes |
320 pmol/min/mg protein (sd=80)
|
Takemoto et al., 2003 - Takemoto, K., Yamazaki, H., Tanaka, Y., Nakajima, M. and Yokoi, T. (2003) Catalytic activities of cytochrome P450 enzymes and UDP-glucuronosyltransferases involved in drug metabolism in rat everted sacs and intestinal microsomes. Xenobiotica 33, 43-55.
|
phase I metabolism > CYP2B > pentoxyresorufin O-dealkylation > microsomes |
16.5 pmol/min/mg protein (sd=1.7)
|
Chan et al., 2006 - Chan, P. K., Lu, S. Y., Liao, J. W., Wei, C. F., Tsai, Y. and Ueng, T. H. (2006) Induction and inhibition of cytochrome P450-dependent monooxygenases of rats by fungicide bitertanol. Food Chem Toxicol. 44(12), 2047-57.
|
phase I metabolism > CYP1A2 > methoxyresorufin O-demethylation > microsomes |
16 pmol/min/mg protein (sd=1.4)
|
Chan et al., 2006 - Chan, P. K., Lu, S. Y., Liao, J. W., Wei, C. F., Tsai, Y. and Ueng, T. H. (2006) Induction and inhibition of cytochrome P450-dependent monooxygenases of rats by fungicide bitertanol. Food Chem Toxicol. 44(12), 2047-57.
|
phase I metabolism > CYP1A > 7-ethoxycoumarin O-deethylation > microsomes |
680.14 pmol/min/mg protein (sd=0.43) (k-90%=6.9)
|
Takemoto et al., 2003 - Takemoto, K., Yamazaki, H., Tanaka, Y., Nakajima, M. and Yokoi, T. (2003) Catalytic activities of cytochrome P450 enzymes and UDP-glucuronosyltransferases involved in drug metabolism in rat everted sacs and intestinal microsomes. Xenobiotica 33, 43-55.
Chan et al., 2006 - Chan, P. K., Lu, S. Y., Liao, J. W., Wei, C. F., Tsai, Y. and Ueng, T. H. (2006) Induction and inhibition of cytochrome P450-dependent monooxygenases of rats by fungicide bitertanol. Food Chem Toxicol. 44(12), 2047-57.
|