Organ |
liver |
Age classes |
adolescent |
Gender |
M |
Remark |
150-180 g |
phase I metabolism > epoxide hydrolase > benzo(a)pyrene-4,5-oxide hydrolase > microsomes |
2.39 nmol/min/mg protein (sd=0.27)
|
Catterall et al., 2003 - Catterall, F., McArdle, N.J., Mitchell, L., Papayanni, A., Clifford, M.N. and Ioannides, C. (2003) Hepatic and intestinal cytochrome P450 and conjugase activities in rats treated with black tea theafulvins and theaflavins. Food Chem Toxicol 41, 1141-7.
|
phase I metabolism > CYP4A > lauric acid hydroxylation > microsomes |
1.7 nmol/min/mg protein (sd=0.3)
|
Catterall et al., 2003 - Catterall, F., McArdle, N.J., Mitchell, L., Papayanni, A., Clifford, M.N. and Ioannides, C. (2003) Hepatic and intestinal cytochrome P450 and conjugase activities in rats treated with black tea theafulvins and theaflavins. Food Chem Toxicol 41, 1141-7.
|
phase I metabolism > CYP3A4 > erythromycin N-demethylation > microsomes |
1 nmol/min/mg protein (sd=0.2)
|
Catterall et al., 2003 - Catterall, F., McArdle, N.J., Mitchell, L., Papayanni, A., Clifford, M.N. and Ioannides, C. (2003) Hepatic and intestinal cytochrome P450 and conjugase activities in rats treated with black tea theafulvins and theaflavins. Food Chem Toxicol 41, 1141-7.
|
phase I metabolism > CYP1A2 > methoxyresorufin O-dealkylation > microsomes |
4.6 pmol/min/mg protein (sd=1)
|
Catterall et al., 2003 - Catterall, F., McArdle, N.J., Mitchell, L., Papayanni, A., Clifford, M.N. and Ioannides, C. (2003) Hepatic and intestinal cytochrome P450 and conjugase activities in rats treated with black tea theafulvins and theaflavins. Food Chem Toxicol 41, 1141-7.
|
phase II metabolism > UGT > 2-aminophenol glucuronidation > microsomes |
24 pmol/min/mg protein (sd=6)
|
Catterall et al., 2003 - Catterall, F., McArdle, N.J., Mitchell, L., Papayanni, A., Clifford, M.N. and Ioannides, C. (2003) Hepatic and intestinal cytochrome P450 and conjugase activities in rats treated with black tea theafulvins and theaflavins. Food Chem Toxicol 41, 1141-7.
|
phase II metabolism > SULT > 2-naphthol sulfation > cytosol |
0.12 nmol/min/mg protein (sd=0.05)
|
Catterall et al., 2003 - Catterall, F., McArdle, N.J., Mitchell, L., Papayanni, A., Clifford, M.N. and Ioannides, C. (2003) Hepatic and intestinal cytochrome P450 and conjugase activities in rats treated with black tea theafulvins and theaflavins. Food Chem Toxicol 41, 1141-7.
|
phase II metabolism > GST > dichloronitrobenzene glutathion conjugation > cytosol |
0.82 μmol/min/mg protein (sd=0.13)
|
Catterall et al., 2003 - Catterall, F., McArdle, N.J., Mitchell, L., Papayanni, A., Clifford, M.N. and Ioannides, C. (2003) Hepatic and intestinal cytochrome P450 and conjugase activities in rats treated with black tea theafulvins and theaflavins. Food Chem Toxicol 41, 1141-7.
|
phase II metabolism > GST > chlorodinitrobenzene glutathion conjugation > cytosol |
19.5 nmol/min/mg protein (sd=3.4)
|
Catterall et al., 2003 - Catterall, F., McArdle, N.J., Mitchell, L., Papayanni, A., Clifford, M.N. and Ioannides, C. (2003) Hepatic and intestinal cytochrome P450 and conjugase activities in rats treated with black tea theafulvins and theaflavins. Food Chem Toxicol 41, 1141-7.
|