Organ |
liver |
Age classes |
adolescent |
Gender |
M |
phase I metabolism > CYP content > microsomes |
0.52 nmol/min/mg protein (sd=0.2) (k-90%=1.4)
|
Chan et al., 2006 - Chan, P. K., Lu, S. Y., Liao, J. W., Wei, C. F., Tsai, Y. and Ueng, T. H. (2006) Induction and inhibition of cytochrome P450-dependent monooxygenases of rats by fungicide bitertanol. Food Chem Toxicol. 44(12), 2047-57.
Fukushima et al., 2008 - Fukushima, S., Okuno, H., Shibatani, N., Nakahashi, Y., Seki, T. and Okazaki, K. (2008) Effect of biliary obstruction and internal biliary drainage on hepatic cytochrome P450 isozymes in rats. World Journal of Gastroenterology 14(16), 2556-60.
|
phase I metabolism > CYP2E1 > aniline 4-hydroxylation > microsomes |
0.6 nmol/min/mg protein (sd=0.1) (k-90%=1.2)
|
Chan et al., 2006 - Chan, P. K., Lu, S. Y., Liao, J. W., Wei, C. F., Tsai, Y. and Ueng, T. H. (2006) Induction and inhibition of cytochrome P450-dependent monooxygenases of rats by fungicide bitertanol. Food Chem Toxicol. 44(12), 2047-57.
Fukushima et al., 2008 - Fukushima, S., Okuno, H., Shibatani, N., Nakahashi, Y., Seki, T. and Okazaki, K. (2008) Effect of biliary obstruction and internal biliary drainage on hepatic cytochrome P450 isozymes in rats. World Journal of Gastroenterology 14(16), 2556-60.
|
phase I metabolism > CYP2B > pentoxyresorufin O-dealkylation > microsomes |
14.6 pmol/min/mg protein (sd=1.9)
|
Jewell and O'Brien, 1999 - Jewell, C. and O’Brien, N.M. (1999) Effect of dietary supplementation with carotenoids on xenobiotic metabolizing enzymes in the liver, lung, kidney and small intestine of the rat. Br J Nutr 81, 235-42.
|
phase I metabolism > CYP1A2 > methoxyresorufin O-demethylation > microsomes |
20.81 pmol/min per mg protein (sd=1.42) (k-90%=562.8)
|
Sugiyama et al., 2006 - Sugiyama, T., Nagata, J., Yamagishi, A., Endoh, K., Saito, M., Yamada, K., Yamada, S. and Umegaki, K. (2006) Selective protection of curcumin against carbon tetrachloride-induced inactivation of hepatic cytochrome P450 isozymes in rats. Life Sci 78, 2188-93.
Jewell and O'Brien, 1999 - Jewell, C. and O’Brien, N.M. (1999) Effect of dietary supplementation with carotenoids on xenobiotic metabolizing enzymes in the liver, lung, kidney and small intestine of the rat. Br J Nutr 81, 235-42.
|
phase I metabolism > CYP1A2 > ethoxycoumarin O-demethylation > microsomes |
90.4 - 146.8 pmol/min/mg protein
|
Fukushima et al., 2008 - Fukushima, S., Okuno, H., Shibatani, N., Nakahashi, Y., Seki, T. and Okazaki, K. (2008) Effect of biliary obstruction and internal biliary drainage on hepatic cytochrome P450 isozymes in rats. World Journal of Gastroenterology 14(16), 2556-60.
|
phase I metabolism > CYP1A2 > aminophylline N-demethylation > microsomes |
6.42 - 9.69 nmol/min/mg protein
|
Fukushima et al., 2008 - Fukushima, S., Okuno, H., Shibatani, N., Nakahashi, Y., Seki, T. and Okazaki, K. (2008) Effect of biliary obstruction and internal biliary drainage on hepatic cytochrome P450 isozymes in rats. World Journal of Gastroenterology 14(16), 2556-60.
|
phase II metabolism > GST > dichloronitrobenzene glutathion conjugation > cytosol |
396 nmol/min/mg protein (sd=0.18) (k-90%=2.2)
|
Sugiyama et al., 2006 - Sugiyama, T., Nagata, J., Yamagishi, A., Endoh, K., Saito, M., Yamada, K., Yamada, S. and Umegaki, K. (2006) Selective protection of curcumin against carbon tetrachloride-induced inactivation of hepatic cytochrome P450 isozymes in rats. Life Sci 78, 2188-93.
Jewell and O'Brien, 1999 - Jewell, C. and O’Brien, N.M. (1999) Effect of dietary supplementation with carotenoids on xenobiotic metabolizing enzymes in the liver, lung, kidney and small intestine of the rat. Br J Nutr 81, 235-42.
|
phase I metabolism > CYP1A2 > methoxyresorufin O-demethylation |
31.76 pmol//min/mg protein (sd=1.34)
|
Krajka-Kuzniak et al., 2015 - Krajka-Kuzniak, V., Szaefer, H., Ignatowicz, E., Adamska, T., Markowski, J., & Baer-Dubowska, W. (2015). Influence of cloudy apple juice on n-nitrosodiethylamine-induced liver injury and phases i and ii biotransformation enzymes in rat liver. Acta Pol. Pharm, 72, 267-276.
|
phase I metabolism > CYP1A1 > ethoxyresorufin O-deethylation |
35.14 pmol/min/mg protein (sd=1.57)
|
Krajka-Kuzniak et al., 2015 - Krajka-Kuzniak, V., Szaefer, H., Ignatowicz, E., Adamska, T., Markowski, J., & Baer-Dubowska, W. (2015). Influence of cloudy apple juice on n-nitrosodiethylamine-induced liver injury and phases i and ii biotransformation enzymes in rat liver. Acta Pol. Pharm, 72, 267-276.
|
phase I metabolism > CYP2B > pentoxyresorufin O-depentylation |
14.81 pmol/min/mg protein (sd=0.88)
|
Krajka-Kuzniak et al., 2015 - Krajka-Kuzniak, V., Szaefer, H., Ignatowicz, E., Adamska, T., Markowski, J., & Baer-Dubowska, W. (2015). Influence of cloudy apple juice on n-nitrosodiethylamine-induced liver injury and phases i and ii biotransformation enzymes in rat liver. Acta Pol. Pharm, 72, 267-276.
|
phase I metabolism > CYP2E1 > p-nitrophenol hydroxylase |
578.13 pmol/min/mg protein (sd=54.83)
|
Krajka-Kuzniak et al., 2015 - Krajka-Kuzniak, V., Szaefer, H., Ignatowicz, E., Adamska, T., Markowski, J., & Baer-Dubowska, W. (2015). Influence of cloudy apple juice on n-nitrosodiethylamine-induced liver injury and phases i and ii biotransformation enzymes in rat liver. Acta Pol. Pharm, 72, 267-276.
|
phase II metabolism > GST > 1-chloro-2,4-dinitrobenzene |
992.95 mol/min/mg protein (sd=41.44)
|
Krajka-Kuzniak et al., 2015 - Krajka-Kuzniak, V., Szaefer, H., Ignatowicz, E., Adamska, T., Markowski, J., & Baer-Dubowska, W. (2015). Influence of cloudy apple juice on n-nitrosodiethylamine-induced liver injury and phases i and ii biotransformation enzymes in rat liver. Acta Pol. Pharm, 72, 267-276.
|
enzyme activity > lactate dehydrogenase |
3312 IU/L (sd=1018)
|
Nagai et al., 2015 - Nagai, K., Yoshida, N., Kiyama, M., Kasahara, K., Yamamura, A., & Konishi, H. (2015). Decreased elimination clearance of midazolam by doxorubicin through reductions in the metabolic activity of hepatic CYP3A in rats. Xenobiotica, 45(10), 874-880.
|
phase I metabolism > CYP1A1 > methoxyresorufin-O-demethylation |
0.18 pmol/min/mg protein (sd=0.03)
|
Suwannakul et al., 2015 - Suwannakul, N., Punvittayagul, C., Jarukamjorn, K., & Wongpoomchai, R. (2015). Purple rice bran extract attenuates the aflatoxin B1-induced initiation stage of hepatocarcinogenesis by alteration of xenobiotic metabolizing enzymes. Asian Pac J Cancer Prev, 16(8), 3371-3376.
|
phase I metabolism > CYP1A2 > ethoxyresorufin-O-deethylation |
0.25 pmol/min/mg protein (sd=0.03)
|
Suwannakul et al., 2015 - Suwannakul, N., Punvittayagul, C., Jarukamjorn, K., & Wongpoomchai, R. (2015). Purple rice bran extract attenuates the aflatoxin B1-induced initiation stage of hepatocarcinogenesis by alteration of xenobiotic metabolizing enzymes. Asian Pac J Cancer Prev, 16(8), 3371-3376.
|
phase I metabolism > CYP3A2 > erythromycin N-demethylation |
12.45 pmol/min/mg protein (sd=1.64)
|
Suwannakul et al., 2015 - Suwannakul, N., Punvittayagul, C., Jarukamjorn, K., & Wongpoomchai, R. (2015). Purple rice bran extract attenuates the aflatoxin B1-induced initiation stage of hepatocarcinogenesis by alteration of xenobiotic metabolizing enzymes. Asian Pac J Cancer Prev, 16(8), 3371-3376.
|
phase II metabolism > UGT |
36.07x10-3 U/mg protein (sd=4.26)
|
Suwannakul et al., 2015 - Suwannakul, N., Punvittayagul, C., Jarukamjorn, K., & Wongpoomchai, R. (2015). Purple rice bran extract attenuates the aflatoxin B1-induced initiation stage of hepatocarcinogenesis by alteration of xenobiotic metabolizing enzymes. Asian Pac J Cancer Prev, 16(8), 3371-3376.
|
phase II metabolism > GST |
70.44x10-2 U/mg protein (sd=5.00)
|
Suwannakul et al., 2015 - Suwannakul, N., Punvittayagul, C., Jarukamjorn, K., & Wongpoomchai, R. (2015). Purple rice bran extract attenuates the aflatoxin B1-induced initiation stage of hepatocarcinogenesis by alteration of xenobiotic metabolizing enzymes. Asian Pac J Cancer Prev, 16(8), 3371-3376.
|