Organ |
liver |
Age classes |
adolescent |
Gender |
F+M |
Condition |
12-17 years |
volume |
0.91 - 1.88 l
|
Nong et al., 2006 - Nong, A., McCarver, D.G., Hines, R.N. and Krishnan, K. (2006) Modeling interchild differences in pharmacokinetics on the basis of subject-specific data on physiology and hepatic CYP2E1 levels: a case study with toluene. Toxicol Appl Pharmacol 214, 78-87.
|
phase I metabolism > CYP2E1 > antibodies > microsomes |
23.1 - 86.1 pmol/mg protein
|
Nong et al., 2006 - Nong, A., McCarver, D.G., Hines, R.N. and Krishnan, K. (2006) Modeling interchild differences in pharmacokinetics on the basis of subject-specific data on physiology and hepatic CYP2E1 levels: a case study with toluene. Toxicol Appl Pharmacol 214, 78-87.
|
blood flow |
0.77 - 1.87 l/min
|
Nong et al., 2006 - Nong, A., McCarver, D.G., Hines, R.N. and Krishnan, K. (2006) Modeling interchild differences in pharmacokinetics on the basis of subject-specific data on physiology and hepatic CYP2E1 levels: a case study with toluene. Toxicol Appl Pharmacol 214, 78-87.
|