Organ |
liver > bile |
Age classes |
adolescent |
Gender |
M |
Remark |
200-250 g |
rate of composition > β-muricholate |
1.35 nmol/min/g liver (sd=0.35)
|
Akoume et al., 2003 - Akoume, M.Y., Perwaiz, S., Yousef, I.M.,Plaa, G.L. (2003) Synergistic role of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7alpha-hydroxylase in the pathogenesis of manganese-bilirubin-induced cholestasis in rats. Toxicol. Sci. 73: 378-85.
|
rate of composition > α-muricholate |
1.07 nmol/min/g liver (sd=0.39)
|
Akoume et al., 2003 - Akoume, M.Y., Perwaiz, S., Yousef, I.M.,Plaa, G.L. (2003) Synergistic role of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7alpha-hydroxylase in the pathogenesis of manganese-bilirubin-induced cholestasis in rats. Toxicol. Sci. 73: 378-85.
|
rate of composition > ursodeoxycholate |
0.94 nmol/min/g liver (sd=0.13)
|
Akoume et al., 2003 - Akoume, M.Y., Perwaiz, S., Yousef, I.M.,Plaa, G.L. (2003) Synergistic role of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7alpha-hydroxylase in the pathogenesis of manganese-bilirubin-induced cholestasis in rats. Toxicol. Sci. 73: 378-85.
|
rate of composition > taurine conjugates > trihydroxyl-bile acids |
10.18 nmol/min/g liver (sd=0.98)
|
Akoume et al., 2003 - Akoume, M.Y., Perwaiz, S., Yousef, I.M.,Plaa, G.L. (2003) Synergistic role of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7alpha-hydroxylase in the pathogenesis of manganese-bilirubin-induced cholestasis in rats. Toxicol. Sci. 73: 378-85.
|
rate of composition > taurine conjugates > tetrahydroxyl-bile acids |
0.12 nmol/min/g liver (sd=0.05)
|
Akoume et al., 2003 - Akoume, M.Y., Perwaiz, S., Yousef, I.M.,Plaa, G.L. (2003) Synergistic role of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7alpha-hydroxylase in the pathogenesis of manganese-bilirubin-induced cholestasis in rats. Toxicol. Sci. 73: 378-85.
|
rate of composition > taurine conjugates > dihydroxyl-bile acids |
1.97 nmol/min/g liver (sd=0.55)
|
Akoume et al., 2003 - Akoume, M.Y., Perwaiz, S., Yousef, I.M.,Plaa, G.L. (2003) Synergistic role of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7alpha-hydroxylase in the pathogenesis of manganese-bilirubin-induced cholestasis in rats. Toxicol. Sci. 73: 378-85.
|
rate of composition > lithocholate |
0.14 nmol/min/g liver (sd=0.05)
|
Akoume et al., 2003 - Akoume, M.Y., Perwaiz, S., Yousef, I.M.,Plaa, G.L. (2003) Synergistic role of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7alpha-hydroxylase in the pathogenesis of manganese-bilirubin-induced cholestasis in rats. Toxicol. Sci. 73: 378-85.
|
rate of composition > glycine conjugates > trihydroxyl-bile acids |
6.2 nmol/min/g liver (sd=0.53)
|
Akoume et al., 2003 - Akoume, M.Y., Perwaiz, S., Yousef, I.M.,Plaa, G.L. (2003) Synergistic role of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7alpha-hydroxylase in the pathogenesis of manganese-bilirubin-induced cholestasis in rats. Toxicol. Sci. 73: 378-85.
|
rate of composition > glycine conjugates > tetranohydroxyl-bile acids |
0.08 nmol/min/g liver (sd=0.04)
|
Akoume et al., 2003 - Akoume, M.Y., Perwaiz, S., Yousef, I.M.,Plaa, G.L. (2003) Synergistic role of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7alpha-hydroxylase in the pathogenesis of manganese-bilirubin-induced cholestasis in rats. Toxicol. Sci. 73: 378-85.
|
rate of composition > glycine conjugates > dihydroxyl-bile acids |
0.83 nmol/min/g liver (sd=0.05)
|
Akoume et al., 2003 - Akoume, M.Y., Perwaiz, S., Yousef, I.M.,Plaa, G.L. (2003) Synergistic role of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7alpha-hydroxylase in the pathogenesis of manganese-bilirubin-induced cholestasis in rats. Toxicol. Sci. 73: 378-85.
|
rate of composition > deoxycholate |
0.84 nmol/min/g liver (sd=0.21)
|
Akoume et al., 2003 - Akoume, M.Y., Perwaiz, S., Yousef, I.M.,Plaa, G.L. (2003) Synergistic role of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7alpha-hydroxylase in the pathogenesis of manganese-bilirubin-induced cholestasis in rats. Toxicol. Sci. 73: 378-85.
|
rate of composition > cholate |
21.63 nmol/min/g liver (sd=2.25)
|
Akoume et al., 2003 - Akoume, M.Y., Perwaiz, S., Yousef, I.M.,Plaa, G.L. (2003) Synergistic role of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7alpha-hydroxylase in the pathogenesis of manganese-bilirubin-induced cholestasis in rats. Toxicol. Sci. 73: 378-85.
|
rate of composition > chenodeoxycholate |
1.56 nmol/min/g liver (sd=0.7)
|
Akoume et al., 2003 - Akoume, M.Y., Perwaiz, S., Yousef, I.M.,Plaa, G.L. (2003) Synergistic role of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7alpha-hydroxylase in the pathogenesis of manganese-bilirubin-induced cholestasis in rats. Toxicol. Sci. 73: 378-85.
|