phase I metabolism > CYP1A2 > caffeine, clearance > microsomes
1.4 ml/min/kg
Alcorn and McNamara, 2002 - Alcorn, J. and McNamara, P.J. (2002) Ontogeny of hepatic and renal systemic clearance pathways in infants: part I. Clin Pharmacokinet 41, 959-98.