Organ |
lung |
Age classes |
adolescent |
Gender |
M |
Condition |
8 weeks |
Remark |
230-270 g |
phase I metabolism > esterase > O-butyryl propanolol hydrolysis > microsomes |
1.93 nmol/min/mg protein (sd=0.08)
|
Imai et al., 2003 - Imai, T., Yoshigae, Y., Hosokawa, M., Chiba, K. and Otagiri, M. (2003) Evidence for the involvement of a pulmonary first-pass effect via carboxylesterase in the disposition of a propranolol ester derivative after intravenous administration. J Pharmacol Exp Ther 307, 1234-42.
|
phase I metabolism > esterase > O-butyryl propanolol hydrolysis > cytosol |
1.64 nmol/min/mg protein (sd=0.17)
|
Imai et al., 2003 - Imai, T., Yoshigae, Y., Hosokawa, M., Chiba, K. and Otagiri, M. (2003) Evidence for the involvement of a pulmonary first-pass effect via carboxylesterase in the disposition of a propranolol ester derivative after intravenous administration. J Pharmacol Exp Ther 307, 1234-42.
|
phase I metabolism > aldehyde dehydrogenase > p-nitrophenylacetate > microsomes |
350 nmol/min/mg protein (sd=35.7)
|
Imai et al., 2003 - Imai, T., Yoshigae, Y., Hosokawa, M., Chiba, K. and Otagiri, M. (2003) Evidence for the involvement of a pulmonary first-pass effect via carboxylesterase in the disposition of a propranolol ester derivative after intravenous administration. J Pharmacol Exp Ther 307, 1234-42.
|