Anatomical, physiological and biochemical differences are the main factors that cause discrepancy between human and animals with respect to the kinetics of xenobiotics. Therefore, insight into the consequences of interspecies differences in anatomy, physiology and biochemically on the kinetics of various classes of compounds may lead to smarter design of animal experiments in terms of choice of animal species, strain, sex and age and subsequently to improved animal human extrapolation.

On the next pages you can find more information on the organs available in this database. For each organ, a general description is given. For some organs, species specific information is added to this.  

On the page 'species information' you can find information about the animal species which are included in the database.