Anatomical, physiological and biochemical differences are the main factors that cause discrepancy between human and animals with respect to the kinetics of xenobiotics. Therefore, insight into the consequences of interspecies differences in anatomy, physiology and biochemical processes on the kinetics of various classes of compounds may lead to improved animal-human extrapolation.
In this database you will find data on the following species: mouse, rat, rabbit, dog, monkey, and pig. These species were selected because they are commonly used in studies on kinetics and toxicology of xenobiotics for the prediction of the human kinetics and toxicity.
The physiological parameters for the mouth, oesophagus, stomach, small and large intestine, liver, gallbladder, kidney and lung were researched in literature and added to the interspecies database.
On the page 'organ information' you can find information about the organs which are included in this database.